earticle

영어

Apolipoprotein A-1 (apoA-I) forms discoidal membrane structure with phospholipids during the formation of high density lipoprotein (HDL) and plays a role in reverse cholesterol transport pathway. The discoidal membrane nanostructure, so called Nanodisc, can be easily assembled in vitro using apoA-I and phospholipids. As well as this easy assembly process, the small size, Sushi-like structure, particle size uniformity, and robustness in solution of the Nanodisc gives us a sense of various ways of biotechnological applications, which might be drug delivery system,
membrane protein host or therapeutics for cardiovascular diseases. Coenzyme Q10 (CoQ10) is a fat-soluble, vitamin-like substance found in the cells of many organisms. It is used as a nutritional supplement and is beneficial in the treatment of human conditions. [1; 2]. The use of CoQ10 is also gaining popularity in the cosmetic industry owing to its antioxidant properties.In spite of the versatility of CoQ10, the molecule's long side chain of 10 isoprenoid units make CoQ10 poorly water-soluble, limiting its bioavailability and more various applications. In the present study, a novel CoQ10 nanoparticle was assembled by encircling isoprenyl chains with
human apolipoprotein A-I protein (apoA-I). This nanostructure of CoQ10 is quite reminiscent of nascent high density lipoprotein (HDL) particle composed of phospholipids and cholesterol.