earticle

영어

Though the activation of c-Jun NH2-terminal kinase (JNK) has been reported to be essential forautophagic cell death in response to various stressors, the molecular links between JNKactivation and autophagic cell death signaling remain elusive. Here we report that, in the JNKdependent autophagic cell death of HCT116 cells induced by an agonistic antibody
against human death receptor 5, JNK activation upregulated Beclin-1 expression and induced Bcl-2 and p53 phosphorylation, suggesting that JNK activation and its consequent fluxes into the proautophagic signaling pathways contribute to the autophagic cell death in cancer cells.