원문정보
초록
영어
Poly (2-hydroxyethyl methacrylate) (pHEMA) is a common synthetic, hydrogel material that is frequently used as a biomaterial due to their high water content, non-toxicity and favorable tissue compatibility, which leads to many applications such as bio-compatible materials including soft contact lenses, kidney dialysis systems, drug-delivery systems and artificial lever support systems. Because of hydrophilic material`s poor interface cells, cell adhesion was weaker on pHEMA, as a significant fraction of the fibroblasts revealed a lack of spreading, with most cells remaining spherical. However, cell adhesion on pHEMA is needed for versatile bio-applications. In this work, GPTMS was used for surface modification of pHEMA to have epoxy groups
exposed on the surface of the material. The coupling reaction was happened between methoxy groups of GPTMS and hydroxyl groups of pHEMA. The characteristic of epoxy group that helps cell adhesion on the surface of pHEMA could be suitable to measure of intensity depended on various concentration of protein. Therefore, it can be applied to detect protein as a bio-sensor.