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식품 및 바이오신소재

Anticancer Activities of Spirulina maxima Extracted by Different Extraction Solvents

원문정보

SungHo OH, JaeGun HAN, JiHye HA, Young KIM, Seung Seop KIM, MyeongHoon JEONG, HyangSuk JEONG, MinChul KWON, DoHyung KANG, WonByong YOON, HyeonYong LEE

한국생물공학회 한국생물공학회 학술대회 2009 춘계학술대회 및 국제심포지움 2009.04 pp.157-157
피인용수 : 0건 (자료제공 : 네이버학술정보)

초록

영어

Anticancer effect and cell cytotoxicity of Spirulina maxima was studied. Spirulina maxima
was extracted with three different solvents: 1)EtOH at 80℃, 2)water at 100℃, and 3)ultrasonification in water at 60℃. The yield at each solvent was 10.3%, 19.8%, and 33.46%, respectively. Each extract was applied to HEK293 to investigate the cell cytotoxicity of normal cells. Lower than 26% of cytotoxicity was observed at 1.0 mℓ of each extract in HEK293, and such low value proved that the extracts are harmless for human body. Anticancer activity was investigated with A549, AGS, Hep3B, MCF-7. Over 70% of anticancer activity was observed at 1.0 mg/mℓ of extracts. The extract from ultrasonification in water at 60℃ showed the highest anticancer activity. Selectivity to each cancer cell was in a good range, 1.5 to 4. This study showed that Spirulina maxima may contain many active components for anticancer. Further chemical analysis will confirm that Spirulina maxima is a useful natural ingredient to extract active components for anticancer.

키워드

저자정보

  • SungHo OH Dept. of Biomaterials Engineering College of Bioscience and Biotechnology, Kangwon National University
  • JaeGun HAN Dept. of Biomaterials Engineering College of Bioscience and Biotechnology, Kangwon National University
  • JiHye HA Dept. of Biomaterials Engineering College of Bioscience and Biotechnology, Kangwon National University
  • Young KIM Dept. of Biomaterials Engineering College of Bioscience and Biotechnology, Kangwon National University
  • Seung Seop KIM Dept. of Biomaterials Engineering College of Bioscience and Biotechnology, Kangwon National University
  • MyeongHoon JEONG Dept. of Biomaterials Engineering College of Bioscience and Biotechnology, Kangwon National University
  • HyangSuk JEONG Dept. of Biomaterials Engineering College of Bioscience and Biotechnology, Kangwon National University
  • MinChul KWON Dept. of Biomaterials Engineering College of Bioscience and Biotechnology, Kangwon National University
  • DoHyung KANG Korea Ocean Research & Development Institute
  • WonByong YOON Dept. of Food Science & Biotechnology College of Bioscience and Biotechnology, Kangwon National University
  • HyeonYong LEE 31)Dept. of Biomaterials Engineering College of Bioscience and Biotechnology, Kangwon National University, Chunchon 200-701, Korea 2)Research Institute of Bioscience and Biotechnology, Kangwon 2)Research Institute of Bioscience and Biotechnology, Kangwon

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