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Non-linear Flux Blanace Analysis of Clostridium acetobutylicum ATCC 824 Using a Genome-scale Model

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영어

Clostridium acetobutylicum is an attention-grabbing bacterium in that it produces several solvents, especially butan-1-ol. We reconstructed a genome-scale metabolic network of C. acetobutylicum ATCC 824 which comprises 502 reactions and 479 metabolites. Then, we carried out flux balance analysis using both linear and non-linear approach which is a modification of previous studies.1,2) Here, we present metabolic features and feasibilities of C. acetobutylicum, and hypothetical annotations derived during the reconstruction of the network. [This work was supported by the Korea–Australia Collaborative Research Project on the Development of Sucrose-Based Bioprocess Platform (N02071165) from the Korean Ministry of Knowledge Economy. Further support by LG Chem Chair Professorship and Microsoft are appreciated.]

저자정보

  • Jaeeun OH Department of Chemical & Biomolecular Engineering, KAIST, Daejeon, 305-701.
  • Hongseok YUN Department of Chemical & Biomolecular Engineering, KAIST, Daejeon, 305-701.
  • Joungmin LEE Department of Chemical & Biomolecular Engineering, KAIST, Daejeon, 305-701.
  • Sang Yup LEE Department of Chemical & Biomolecular Engineering, KAIST, Daejeon, 305-701.

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