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유전자 및 대사공학 분야

Pathway analysis and it application for succinic acid in Mannheimia succiniciproducens and Escherichia coli

원문정보

Yong J CHOI, Tae Yong KIM,, Hyung Rok CHOI, Sang Yup LEE

한국생물공학회 한국생물공학회 학술대회 2009 춘계학술대회 및 국제심포지움 2009.04 pp.139-139
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초록

영어

Mannheimia succiniciproducens MBEL55E is a capnophilic gram-negative bacterium which efficiently produces succinic acid. In order to analyze metabolic pathways of M. succiniciproducens, we applied pathway analysis to the biochemical network of M. succiniciproducens, previously developed by our group. We then also analyzed the biochemical network of Escherichia coli, in the same way as above, in order to grasp the notable differences between these two organisms. In order to draw clear conclusions, we clustered the solutions of two microorganisms, and compared each other. Each of clusters showed characteristic yield of succinic acid and the number of solutions and clusters of M. succiniciproducens is greater than that of E.coli. [This work was supported by the Genome-based Integrated Bioprocess Project of the Ministry of Education, Science and Technology (No. 2005-01294). Further supports by the LG Chem Chair Professorship, IBM SUR program, and Microsoft are appreciated.

키워드

저자정보

  • Yong J CHOI Department of Chemical and Biomolecular Engineering (BK21 Program), Metabolic and Biomolecular Engineering National Research Laboratory, Center for Systems and Synthetic Biotechnology, Institute for the BioCentury, Korea Advanced Institute of Science and Technology, Daejeon 305-701, Republic of Korea.
  • Tae Yong KIM, Department of Chemical and Biomolecular Engineering (BK21 Program), Metabolic and Biomolecular Engineering National Research Laboratory, Center for Systems and Synthetic Biotechnology, Institute for the BioCentury, Korea Advanced Institute of Science and Technology, Daejeon 305-701, Republic of Korea.
  • Hyung Rok CHOI Department of Chemical and Biomolecular Engineering (BK21 Program), Metabolic and Biomolecular Engineering National Research Laboratory, Center for Systems and Synthetic Biotechnology, Institute for the BioCentury, Korea Advanced Institute of Science and Technology, Daejeon 305-701, Republic of Korea.
  • Sang Yup LEE 1Department of Chemical and Biomolecular Engineering (BK21 Program), Metabolic and Biomolecular Engineering National Research Laboratory, Center for Systems and Synthetic Biotechnology, Institute for the BioCentury, Korea Advanced Institute of Science and Technology, Daejeon 305-701, Republic of Korea, Department of Bio and Brain Engineering, BioProcess Engineering Research Center and Bioinformatics Research Center, Korea Advanced Institute of Science and Technology, Daejeon 305-701, Republic of Korea.

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