earticle

영어

The kinase cascade of the septation initiation network (SIN), first revealed in fission yeast, activates the contraction of the actomyosin ring, and plays an essential role in fungal septation. SmoAp is associated with SIN for septation in A. nidulans. In this study, SmoAinteracting proteins were isolated from the A. nidulans with SmoAFLAG affinity chromatography and mass spectrometry. As a result, 12 SmoA-interacting proteins were isolated and these proteins bypassed the requirement of the SIN kinases for septum formation and conidiation. These proteins also involved in chromatin remodeling process. Therefore, in A. nidulans, SmoA and SmoA-interacting proteins likely have an antagonistic interaction against the SIN pathway to regulate septation and conidiation.