earticle

영어

Obesity is associated with heath risks for chronic diseases such as heart disease, hypertension, diabetes, and cancer. Excess body weight is the result of imbalance between energy intake and energy expenditure, by which stored as triacylglycerol (TAG) in adipose tissue. Recently edible diacylglycerol (DAG) oil has synthesized to reduce serum TAG levels, to decrease hemoglobin A1C level in patients with type 2 diabetes and to prevent the accumulation of body fat in animals and humans with long term safety. Therefore, we synthesized DAG from tuna oil using lipase, and investigated their anti-obesity effects in C57/BL6J mice. Briefly, DAG was produced by glycerolysis of tuna oil with glycerol in a batch bioreactor using a 1,3-regioselective immobilized lipase (Lipozyme RM-IM). Consumption of DAG diet effectively reduced body weight gain, serum cholesterol and triacylglycerol levels as plasma biochemical markers of obesity in C57 BL/6J mice, compared to the high TAG fed group. Moreover, we compared changes in several gene expressions in hepatic and adipose tissue in normal, TAG and DAG diet intake mice models. DAG fed group had a potential effect on several gene expressions in hepatic and adipose tissue.