earticle

영어

Proteomics related toxicology has provided innovative approaches to novel biomarkers screening, toxic materials screening, risk assessments, and predictive toxicology. The application of proteomic analysis in the field of aquatic toxicology has recently started to increase, but until now, little attention has been given to the integrated analysis of molecular responses and higher-level effects within the same study. In this study, protein expression profiles provided significant insights into the toxicity mechanisms for the Daphnia magna, post exposure of heavy metals. We performed proteomic analysis of Daphnia magna in response to Sodium arsenite [As(III)], Sodium arsenate [As(V)], Cadmium nitrate [Cd], As(III)+As(V), As(III)+Cd and As(V)+Cd as a heavy metal, by using two-dimensional gel electrophoresis (2-DE) and found that protein profiles from Daphnia magna were shown different expression patterns for the each heavy metals. In addition, Daphnia magna exposed to the mixture of heavy metals showed different expression patterns. Daphnia magna protein expression profile patterns of binary metal mixtures are not the simple sum of their individual compounds fingerprint.