원문정보
초록
영어
Among many biodegradable polymers, poly(lactic acid) (PLA) has been used most widely for a wide variety of pharmaceutical and biomedical applications such as scaffolds for tissue engineering and carriers for controlled drug release because of its proven biocompatibility and favorable regulatory status. However, the high hydrophobicity of PLA results in some problems in particulate formulation of drugs such as too slow drug release and unfriendly environment to hydrophilic drugs. Poly(ethylene glycol) (PEG) is widely used to cloak particles and obtain stealthy properties. PEG is water-soluble, nonionic, nonantigenic and non-immunogenic. In this study, methoxy poly(ethylene glycol)-b-poly(L-lactic acid) (MPEG-PLLA) diblock copolymer was synthesized via a ring-opening polymerization, and then MPEG-PLLA microparticles were prepared by aerosol solvent extraction system (ASES) using supercritical carbon dioxide as antisolvent. The effects of temperature, pressure, initial concentration and flow rate of polymer solution on the particle size, size distribution, and morphology were investigated.