earticle

영어

We show here that polymeric nanoparticles with sizes of 100 nm and under can be dispersed in the body of nematode C. elegans through the receptor-mediated endocytosis. When we fed animals with 50, 100, 200, and 500 nm polystyrene clusters, only 50 and 100 nm particles
could be delivered to internal organs from intestine. By the loss-offunction mutations in genes related with endocytosis, we found that nanoparticles could be transferred from intestine to neighbor organs through receptor-mediated endocytosis.