earticle

영어

The purpose of this study was to demonstrate the multipotency of periosteum-derived progenitor cells (PDPCs) as alternative cell sources and their regenerative capacity in articular cartilage.
Successful differentiation of PDPCs into mesodermal lineages such as chondrocytes, osteocytes, and adipocytes was demonstrated by realtime RT-PCR and histological analyses. In addition, after transplantation of cell-atelocollagen constructs, tissue engineered cartilage into defected site of rabbit, regeneration of the injured sites was observed. These results imply that these cells can be successfully used as an alternative source for the regeneration of injured tissues or organs. Multipotent adult stem cells will be useful sources in wide-raging applications of cell therapy in the near future.