원문정보
초록
영어
Oxanine (Oxa), one of the major products from nitrosative oxidation of guanine (1, 2), has O-acylisourea structure in its base-ring, which can show the amine-directed reactivity (3). As shown in Figure 1, Oxa was found to induce DNA-protein crosslink (DPC) formation with
nucleophilic moiety of biomolecule (4). In this study, Oxa-induced DPC formation was designed by designing synthetic Oxa-containing DNA duplex (5) and explored more in terms of its biotechnological applications and synthetic biological significances. Since DPC complexes can show two biological functions originated from DNA and protein, Oxa-induced DPC complexes can be usefully employed as synthetic biological model substrates for analyzing the molecular
mechanism in cellular system.