earticle

영어

To evaluate the anticolitic effect of red ginseng (RG, the steamed root of Panax ginseng C.A. Meyer, Araliaceae),RG and its representative constituents, ginsenosides Rg3 and Rh2, were orally administered to dextran sulfate sodium (DSS)-induced colitic mice and inflammatory markers investigated. RG and its constituents, ginsenosides Rg3 and Rh2, inhibitedcolon shortening and myeloperoxidase activity induced by DSS. The ginsenosides Rg3 and Rh2 inhibited mRNA expressionof interleukin (IL)-1β as well as protein levels of IL-1β and IL-6. These ginsenosides also inhibited the activation of atranscription nuclear factor (NF)-κB. Ginsenoside Rh2 was a more potent inhibitor than ginsenoside Rg3. The anticoliticeffects of these ginsenosides were comparable with sulfasalazine.