earticle

논문검색

RESEARCH NOTE

Equol Modulates Induction of Hepatic CYP 1A1, 1B1, and AhR in Mice Treated with 7,12-Dimethylbenz(a)anthracene

원문정보

Eun Jeong Choi, Gun-Hee Kim

한국식품과학회 Food Science and Biotechnology Volume 18 Number 1 2009.02 pp.245-248
피인용수 : 0건 (자료제공 : 네이버학술정보)

초록

영어

Present study was investigated the hepatic effects of equol on the 7,12-dimethylbenz(a)anthracene (DMBA)-induced enzymatic activity and expression of CYP1Al and CYP1B1 in mice. Equol was administered orally at 5 and 25mg/kg BW for 4 weeks. Subsequently, mice pretreated with equol received DMBA intragastrically twice a week for 2 weeks.DMBA induced CYP1 activity as well as the expression of CYP1A1 and CYP1B1. Each of these effects was significantlyreduced by equol in dose-dependent manner (p<0.05). Equol also reduced the relative AhR mRNA expression, similar to itseffect on CYP1A1. These results suggest that equol modulates the CYP1A1 through a reduction of AhR expression in micetreated with DMBA.

목차

Abstract
 Introduction
 Materials and Methods
 Results and Discussion
 References

키워드

저자정보

  • Eun Jeong Choi Plant Resources Research Institute, Duksung Women’s University, Seoul 132-714, Korea
  • Gun-Hee Kim Plant Resources Research Institute, Duksung Women’s University, Seoul 132-714, Korea

참고문헌

자료제공 : 네이버학술정보

    함께 이용한 논문

      ※ 원문제공기관과의 협약기간이 종료되어 열람이 제한될 수 있습니다.

      0개의 논문이 장바구니에 담겼습니다.