earticle

영어

This study examined the antioxidative activity of delphinidin, a kind of anthocyanidin from eggplant. Cellularprotective potential from oxidative damage by nitric oxide (NO), superoxide anion (O2−), and peroxynitrite (ONOO−) usingepithelial cell line LLC-PK1 cell as well as in vitro radical scavenging effects were investigated. Delphinidin showed strong invitro radical scavenging effects against NO, O2−, and hydroxyl radical (·OH) in dose-dependent manners. In addition,delphinidin increased cell viability in LLC-PK1 cells in a concentration-dependent manner when viability was reduced byONOO−-induced oxidative damage. To elucidate the protective mechanisms of delphinidin from ONOO−, sodiumnitroprusside (SNP), and pyrogallol were also employed to generate NO and O2−, respectively. The treatment of delphinidinrecovered reductions in cell viability caused by SNP and pyrogallol, indicating that delphinidin can attenuate oxidative stressinduced by NO and O2−. The present study suggests that delphinidin is a promising antioxidative agent.