earticle

영어

Resveratrol-loaded poly(ε-caprolactone) (PCL) nanoparticles were prepared by oil in water (O/W) emulsionsolvent evaporation method. The morphology of the nanoparticles was evaluated using atomic force microscope (AFM), inwhich well-shaped and rigid nanoparticles were prepared. The mean particle size of nanoparticles prepared using onlydichloromethane (DCM) (523.5±36.7nm) was larger than that prepared with a mixture of DCM and either ethanol (EtOH)(494.5±29.2nm) or acetone (493.5±6.9nm). The encapsulation efficiency of nanoparticles prepared only with DCM asdispersed phase (78.3±7.7%) was the highest of those prepared with solvent mixtures. An increase in the molecular weight ofPCL led to an increase in encapsulation efficiency (from 78.3±7.7 to 91.4±3.2%). Pluronic F-127 produced the smallest meansize (523.5±36.7nm) with the narrowest particle size distribution. These results show that dispersed phase, molecular weightof wall materials, emulsion stabilizer could be important factors to affect the properties of nanoparticles.