원문정보
Effect of Glycyrrhizin on the Aoptosis of Melanoma Cells in Mel/ret Transgenic Mice
초록
영어
The effect of glycyrrhizin on melanoma cells was investigated. DNA fragmentation in cultured melanoma cells was promoted by the addition of glycyrrhizin in a dose dependent manner. Administration(i.m.) of glycyrrhizin to Mel/ret transgenic mice resulted in apoptosis induction, reduction of mitochondrial transmembrane potential in melanoma cells. Decreased B220+ B cells were recovered by the treatment of glycyrrhizin in splenocytes and mesenteric lymph node cells, while Thy-1+ T cells were not influenced. Results suggested that glycyrrhizin acted as an inducer of apoptosis of melanoma cells and an immuno-potentiator via recovered B lymphocyte population in Mel/ret transgenic mice.
목차
재료 및 방법
실험 동물
시약 및 기기
DNA fragmentation의 측정
Mitochondrial transmembrane potential(ΔΨm)의 측정
Lymphocyte 아집단 분석
결과 및 고찰
GL이 배양된 melanoma 세포의 apoptosis 에 미치는 효과
GL이 Mel/ret transgenic mice의 melanoma 세포 apoptosis에 미치는 효과
GL이 Met/ret transgenic mice melanoma세포의 mito chondrial transmembrane potential(ΔΨm)에 미치는 효과
GL이 met/ret transgenic micedml lymphocyte 미치는 효과
요약
감사
참고문헌