원문정보
A Study on the Extraction and Efficacy of Bioactive Compound from Hovenia dulcis
초록
영어
The biological activities of extracts from the fruit, stem, and leaf of Hovenia dulcis were examined. In the batch mode of operation, the fruit, stem, and leaf of Hovenia dulcis were extracted with hot water for 10 hr. The fruit extract of Hovenia dulcis gave the highest activity for decreasing alcohol concentration which was 138% of control. The equilibrium between bioactive compound in the fruit (size : 4 mm) and hot water solution was reached within 6 hr and the recovery was 95% by three-times extraction. The fruit extract of Hovenia dulcis showed significant alcohol decrease in blood and hepatoprotective activity against CCl4-toxicity in rat. The fruit extract significantly inhibited the elevation of serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), and lactate dehydrogenase (LDH) levels.
목차
서론
재료 및 방법
식물재료 및 추출 방법
알코올 농도의 분석
알코올분해효소 (alcohol dehydrogenase, ADH)의 활성측정
알데하이드 분해 효소 (aldehyde dehydrogenase,ALDH)의 활성 측정
Rat (SD)에 있어서 혈중 알코올 농도 측정 및 생화학적검사
사염화탄소 (CCl4)에 의한 간 독성 유발
결과 및 고찰
헛개나무 열수 추출물의 알코올 분해 효과
헛개열매 열수 추추물의알코올 및 알데하이드 분해효소 활성에 미치는 영향
헛개열매 추출물의 혈중 알코올 농도 및 AST 저하 효과
사염화탄소 (CCl4)에 의한 간 독성 유발 및 헛개열매 추출물의 간 보호 효과
요약
REFERENCES