earticle

영어

In this research, the chemo-enzymatic synthesis of sorbitan methacrylate was investigated to optimize reaction conditions. Firstly, sorbitan was manufactured by sorbitol cyclic reaction in the presence of ρ-toluenesulfonic acid (ρ-TSA) as catalyst material. Secondly, sorbitan methacrylate was synthesized by immobilized lipase Novozyme 435 with acyl donors in t-butanol. As a result of enzymatic synthesis of sorbitan methacrylate, the conversion yield reached about 65% in the condition of initial sorbitan conc. 50 g/L, enzyme content 3% (w/v), molar ratio 1:3, reaction temperature 50℃ and reaction time 42 hrs using methyl methacrylate as acyl donor. Comparing with acyl donors and reaction temperature, the conversion yield reached
about 18, 65 and 80% with methacrylic acid, methyl methacrylate and vinyl methacrylate as acyl donor, respectively. And optimum reaction temperature was 60, 50, and 50℃, respectively

한국어

당알콜인 솔비톨을 화학촉매 p-TSA로 탈수반응하여 제조한 솔비탄을 고정화 리파제 Novozym 435를 이용하여 솔비탄 메타크릴레이트를 합성하였다. 솔비탄 메타크릴레이트를 효소적으로 합성한 결과 아실 공여체로 메틸 메타크 릴레이트를 사용하여 솔비탄 초기농도 50 g/L, 효소함량 3% (w/v), 몰비 1 : 3, 반응온도 50℃, 반응시간 42시간에서 약 65%의 수율을 얻었다. 아실 공여체의 종류에 따른 수율의 변화에 현격한 차이를 나타내어 methacrylic acid의 경우에 최대 전환율이 60℃에서 약 18%이었고, ethyl
methacrylate의 경우에는 50℃에서 약 65%를 보였으며, 그리고 vinyl methacrylate에서는 50℃에서 약 80%로 가장 높은 전환율을 나타냈다.