earticle

영어

Self-assembled monolayers(SAMs) provide a simple route to functionalize electrode surfaces with organic molecules containing free anchor groups, such as thiols, disulfides, amines, silanes and acids. Self-assembled monolayers allows tremendous flexibility with respect to several applications depending upon their terminal functionality or chain length. SAMs of long chain alkane thiols produce a highly packed and ordered surface, which can provide a membrane like microenvironment(cellular) useful for immobilizing biological molecules. The high selectivity of biological molecules(eg. enzymes, DNA, antibodies and antigens) integrated with an electrochemical, optical or piezoelectric transduction mode of analyte recognition offers great promise for their exploitation as efficient and accurate biosensors. Monolayer design plays a key role in controlling the performance of these SAM based biosensors.