원문정보
Development and Applications of Proteomics Technology
초록
영어
Proteomics research includes identification and quantitation of single protein and/or protein complex, profiling of protein expression changes in response to biological perturbations, characterization of protein functions and interactions, and elucidation the linkage between proteins and diseases. In this review paper, recent developments in the basic technologies
involved in the proteomics research such as 2-dimensional PAGE and mass spectrometry are discussed. Also, the application areas of proteomics technology such as protein expression mapping and cell map proteomics are introduced with the focus on new drug development.
목차
서론
Proteomics 핵심 기술
2-D PAGE
Mass Spectrometry
분석기술의 자동화
Proteomics 응용분야
Protein Expression Mapping
Cell Map Proteomics
Proteomics 기술과 신약개발
질병 표지인자(marker)의 동정 및 Drug Target의 도출
Target의 검증 및 독성 연구
치료방법의 방향 제시
Proteomics 기술의 향후 전망
REFERENCES