earticle

영어

This study was performed to observe the effects of Platycodon grandiflorum A. DC (3 years) extracts on the bronchus diseases bacteria(Mycobacterium sp., K. pneumoniae, F. nucleatum, S. aureus, C. diphtheriae, S. pygogenes and N. gonorrhoeae) and fungi(A. fumigatus). Platycodon grandiflorum A. DC was extracted by ethanol, water, ethyl ether and petroleum ether. The extraction rates of Platycodon grandiflorum A. DC were identified as 71.8%, 100%, 15.4% and 14.1% in each extract solution. Each extract solution was injected into culture media with several concentrations and then the bacteria cell growth was investigated during 32 hours. As a result, the antimicrobial activities of extracts from ethyl ether and petroleum ether were excellent. Among several concentrations, the percentage of bacteria cell growth inhibitions were
observed to be from 0.06% to 0.14%. The rates of antimicrobial activities were over 70%. The degree of cell growth inhibition of each bacteria was appeared in the order of ethyl ether > petroleum ether > water > ethanol.

한국어

도라지에 H2O, ethanol, ethyl ether와 petroleum ether를 용매로 하여 추출한 시료를 기관지질환 유발세균(S. aureus, C. diphtheriae, Mycobacterium sp., F. nucleatum, A. fumicatus, K. pneumoniae, S. pyogenes N. gonorrhoeae)에 투여한 결과 ethyl ether, petroleum ether, H2O와 ethanol의 순으로 항균력이 우수하다는 것이 판명되었다. 특히, ethyl ether에 의한 도라지 추출물의 항균력이 80%이상 뛰어난 효과를 나타내었다.
우수한 항균력을 가지는 도라지 추출물의 농도는 30mg부터 30%이상의 억제작용을 보였으며 70mg에서 70%이상의 세포성장이 저해되는 현상을 관찰하였다. 기관지 질환 유발세균에 대한 도라지의 효과는 대조구에 비해 70%이상의 탁월한 항균효과가 있는 것으로 확인되었다.