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영어

The purpose of this study was to investigate the effect of naringin, one of flavonoids, on the pharmacokinetics and bio-availability of nimodipine in rabbits. Pharmacokinetic parameters of nimodipine were determined in rabbits after oraladministration of nimodipine (16mg/kg) with or without naringin (1, 5 or 15mg/kg). Nimodipine was analyzed byhigh performance liquid chromatography using Hypersil ODS column. Naringin significantly (p<0.05) increased the areaunder the plasma concentration-time curve (AUC) and the peak concentration (Cmax) of nimodipine at 5 and 15mg/kg.The absolute bioavailability (AB%) of nimodipine by prescence of naringin (5 or 15mg/kg) increased from 32.2-36.9%(p<0.05) compared to the control (22.0%). However, presence of naringin had no significant effect on the eliminationrate constant (Kel) of nimodipine. There were no apparent changes of the time of peak concentration (Tmax) of nimo-dipine by coadministration. These results suggest that the increased bioavailability and the significant changes of thesepharmacokinetic parameters of nimodipine by naringin may be attributed to the potential of narigin to inhibit cyto-chrome P450 (CYP) 3A4 and P-glycoprotein efflux pump in the liver and intestinal mucosa.