원문정보
초록
영어
Diabetes mellitus is a metabolic disorder characterized by hyperglycemia. Diabetes mellitus ruins the kidney functions and leads to the development of chronic renal disease. Although the pathogenic mechanism of diabetic renal disease has not been elucidated, cytokine-driven proliferative and inflammatory mechanisms have been suggested to contribute to its progression.(1) Retinoid, a known anti-proliferation and anti-inflammation agent, has been reported to be
beneficial in some experimental models of renal disease.(2) To find the effect of retinoid feeding in streptozotocin (STZ)-induced diabetic renal disease, we performed proteome analysis of rat kidney by the 2-dimensional-electrophoresis (2-DE). In this study, rats were divided into two
groups; one group for STZ-injected rats + retinoid (retinol) supplement feeding and the other group for STZ-injected rats + general feeding. 4 weeks after STZ injection, kidney samples of all rats were homogenized and then analyzed by the 2-DE analysis. In conclusion, 8 proteins were up-regulated and 3 proteins were down regulated in retinoid supplement feeding diabetic rats
compared to general feeding diabetic rats. Further studies of these proteins will help to understand comprehensive retinoid effects on kidney.