원문정보
초록
영어
Self-assembeld nanostructures from amphiphilic molecules have been extensively studied due to their unique characteristics and the variety of applications in many areas.1)-4) Here, we report the synthesis of novel amphiphilic biodegradable polymer and its self-aggregation behavior in aqueous solution. A series of amphiphilic copolymer, poly(2-hydroxyethyl aspartamide) grafted with fatty acids from palm oil (PHEA-g-palm FA) with various degree of substitution (DS, defined as grafted mole percent), was synthesized. Synthetic, hydrophilic poly(amino acid) polymer, PHEA, can be simply prepared by aminolysis of precursor polymer poly(succinimide) (PSI) withethanolamine. Fatty acids were grafted onto the backbone polymer PHEA through DCC/DMAP mediated ester bond (-COO-) formation between PHEA (-OH) and fatty acids (-COOH). Synthesis and DS values were verified with 1H NMR spectra. Stable self-aggregates in aqueous media were successfully prepared by direct dissolution/sonication method. The effect of DS on the self-aggregation was investigated by characterizing the size and structure of self-aggregates with light scattering methods and transmission electron microscopy (TEM).