원문정보
초록
영어
This study was designed to examine the effects of Hydrangea macrophylla var. thunbergii extract (HMTE) on the blood glucose in diabetic rats. Diabetes mellitus was induced in male Institute of Cancer Research (ICR) rats by injection of streptozotocin (STZ) dissolved in a citratebuffer (pH 4.5) into abdominal of 45mg/kg of body weight. The rats' body weights were measured along with plasma level of glucose, total cholesterol (TC), HDL-cholesterol, triglyceride (TG) and free fatty acids (FFA). The experimental groups were divided into 6 groups which consisted of Control (n=12); Normal rats group, C1 (n=12); STZ-induced diabetic rats group, C2 (n=12); STZ-induced diabetic rats with Hydrangea macrophylla var. thunbergii group, C3 (n=12); STZ-induced diabetic rats with hydrangea macrophylla var. thunbergii (50%) +
polygonatum odoratum group (50%), C4 (n=12); STZ-induced diabetic rats with hydrangea macrophylla var. thunbergii (50%)+Cassia tora group (50%), C5 (n=12); STZ-induced diabetic rats with hydrangea macrophylla var. thunbergii (50%) + polygonatum odoratum (25%) + Cassia tora group (25%). Body weight, food intake, HDL-cholesterol, and blood glucose were recorded 6 weeks. The blood glucose concentration of C2 and C5 group were lower than the other groups. There was no significant difference of cholesterol level among diabetic group. The C2 group in
weight, FFA and TG levels significant change among all groups. This study shows that HMTE beneficially modulate blood glucose concentration in diabetic animals.