원문정보
초록
영어
Hottuynia cordata is known as a therapeutic drug that has been used in traditional oriental medicine for the treatment of allergy.(1) And Ulmus davidiana var. japonica is a deciduous broad-leaved tree widely distributed in oriental countries, and its stem and root barks have been used as a traditional medicine for the treatment of edema, mastitis, cancer, inflammation, and rheumatoid arthritis for a long time.(2) This study was on the inhibitory effects of Houttuynia cordata and Ulmus davidiana var. japonica water extracts (HUD) on mast cell mediated allergic reactions. Compound 48/80 was used to activate the mast cells, which is known as a potent inducer of a deregulation and for the release of histamine and other chemical mediators that are responsible for anaphylactic symptoms. HUD inhibited a compound 48/80 induced systemic
anaphylactic shock and a passive cutaneous anaphylactic reaction. In addition, HUD inhibited the itching behavior by a histamine release from mouse skin mast cells stimulated by compound 48/80. These results suggest a possible therapeutic application of this agent to mast cell mediated inflammatory allergic diseases.