원문정보
초록
영어
Mast cells are so widely recognized as critical effecter cells in allergic disorders and other Immunogloblin(Ig)E-associated acquired immune response.(1,2) In addtion, Mast cells (MCs) play an essential role in allergic inflammation, including asthma, atopic dermatitis and allergic rhinitis.(3,4) This study was designed to evaluate whether the Houttuynia cordata and Ulmus davidiana var. japonica water extracts(HUD) could modulate the production of pro-inflammatory
cytokines and mechanism in phorbol 12-myristate 13-acetate(PMA) plus calcium inopore A23187 treated human mast cell line, HMC-1, to prevent the inflammatory response. HUD inhibited inflammatory cytokines such as TNF-α, IL-6 and IL-8 stimulated by PMA pus A23187 from HMC-1 cells. In addition, HUD did not significantly affect cell viability and had no toxicity on HMC-1
cells. Based on these results, HUD can be used for treatment of allergic inflammation response.