원문정보
초록
영어
In living organisms, reactive oxygen species arise from endogenous oxidative metabolism or exogenous stresses, such as UV light, ionizing radiation, and some types of redox agents, causing oxidative damage to proteins, nucleic acids, and unsaturated fatty acids in lipids. Reactive oxygen species and other free radical emissions by cells and tissue are often taken as an indicator and a cause of aging in vitro and in vivo. In the case of MSC however, ROS was also
shown to be involved in signaling, down-regulating proliferation and stimulating apoptosis or differentiation processes. Mesenchymal stem cells (MSC) are of great therapeutic potential because of their ability to self-renew and differentiate into multiple tissues. A hot new topic in medical treatment is the use of MSC in therapy. So we confirmed the changes of hMSC apoptosis caused by ROS using various tools for apoptosis assay. And we performed proteome profiling to find apoptosis associated regulators.