원문정보
초록
영어
In the cascade of neurotransmission, neuronal SNARE proteins play a central role. Neuronal SNARE proteins mediate membrane fusion between presynaptic membrane and synaptic vesicle. By the result of synaptic membrane fusion, a fusion pore is made through which neurotransmitters are released. SNARE complex is thought to generate fundamental force that is required for the membrane fusion. As is well-known, a few types of botulinum neurotoxin have been developed and commercialized for the purpose of cosmetic and therapeutic uses. For
example, Botox, a popular cosmetic agent, is to cleave SNARE proteins disabling neurotransmission. So, it is that SNARE folding modulator may act like Botox by inhibiting the folding of SNARE complex not by cleaving the SNARE proteins. In the present study, we could draw some candidate SNARE folding modulators from phenolic compounds. A few compounds inhibited SNARE complex formation. As expected, the phenolic compounds inhibited membrane fusion and neurotransmitter release from PC12 cells, too. Probably, the phenolic compounds
may play a role as an effective anti-wrinkle agent.