원문정보
초록
영어
Soluble N-ethylmaleimide sensitive factor attachment receptor (SNARE) proteins play crucial role in membrane fusion and exocytosis. SNARE proteins are believed to generate fundamental force that is needed to facilitate the merging of two opposing membranes by forming so called “SNARE complex.” Inhibition of neuronal SNARE complex formation impairs neurotransmitter release.
In the present study, we carried out to examine the effects of synthetic peptides patterned after the α–helical region of the SNARE motifs on SNARE complex formation and neuronal exocytosis. Thirteen 17-mer synthetic peptides were assayed for their abilities to prevent SNARE-driven membrane fusion. Among them, a few synthetic peptides inhibited the membrane fusion by ~70%. Notably, peptides patterned after the N-terminal region of the SNARE motifs had a
stronger effect on membrane fusion than those of middle and C-terminal domains.
The found peptide might function as anti-wrinkle agent by blocking SNARE complex formation while Botox cleaves SNARE proteins. Further, the found peptide might be developed to potential pain-killer.