원문정보
초록
영어
Sun protecting substances are capable of protecting humans from harmful effects solar radiation such as aging and skin cancer (1, 2). Bisethylhexyloxyphenolmethoxyphenyltrizine(BEMT) is one of the most widely used oil-soluble UVA+UVB absorber in sunscreen cosmetic product. Stratum corneum is the major barrier in percutaneous absorption process (3, 4). The purpose of this study is to confirm the skin delivery property and synergistic UV-blocking effect of solid lipid nano-particles containing the BEMT with a sun screen agent. The study of skin permeability is important, and performed by various methods. In this study, target active ingredient is BEMT. I compared in vitro release and penetration of this active ingredient in O/W emulsion and SLN
formulation. According to Wissing, The release rate of oxybenzone is decreased when using SLN formulations compared emulsions (5). As a result, in vitro penetration and release of BEMT is generally higher O/W emulsion than the SLN formulation. After having a 24 hours, cumulative transdermal absorption amount of BEMT is higher emulsion(16.04㎍/㎠) than SLN formulation(4.21㎍/ ㎠). The other hand, in vivo study, penetration of BEMT into the skin was investigated by the stripping method. It was shown that the rate of release could be decreased by 80% in the SLN formulation. SLN matrix sustained release carrier system, therefore sunscreen agent remain longer on the skin. And the occlusive effect of SLN was physical sunscreen with increased synergistic UV-blocking effect (6). In vitro UV protection result, the sun protection factor
(SPF) could be increased by 100% in the SLN formulation. Therefore, BEMT-SLN led synergistic UV-blocking behavior. The BEMT residual content gradually decreased to 80.9% over 12 hours the result of UV radiation, but the residual content of BEMT with an encapsulated solid lipid decreased to only 92.3%. Also the BEMT-SLN led to improve of photochemical stability effect on
ultra violet. Ultimately it appeared that Solid lipid nanoparticle was the most effective to
adopt BEMT and may be used for a useful drug delivery system in the sun care product.