earticle

영어

In the present work, we report the results of a study at evaluating the acetylcholinesterase (AChE) and β-secretase (BACE) inhibitory activity of the solvent extracts from Alnus sp. The fractions of methanol, n-hexane, CH2Cl2, EtOAc and n-buOH extracts were tested for AChE inhibitory activity using the Ellman colorimetric method. The results showed that the MeOH and EtOAc fraction of Alnus sp. at concentration of 1 mg/ml inhibited more than 50% of AChE activity.
The EtOAc extract of Alnus sp. also exerted an inhibitory effect against BACE activity. These finding may contribute to biological significance in that AChE inhibitor has been used as a drug for the symptomatic treatment of Alzheimer's desease.