원문정보
초록
영어
In the present research, a novel ultra-sensitive detection method of β-amyloid 1-40 was investigated by scanning tunneling microscopy (STM). It is known that, β-amyloid 1-40 is a most challenging marker for the early diagnosis of alzheimer disease. So, to achieve this, an ultra-sensitive detection system for β-amyloid 1-40 is required. In this study, novel ultra-sensitive of β-amyloid 1-40 was developed and STM was performed for it's investigation. In STM, the frequency of current peaks was measured in accordance with the surface density of the dispersed Au nanoparticle-antibody complex on the gold surface. Which was represented as periodogram with it's logarithmic regression curve, and the change of the power spectrum was observed in accordance with the concentration of β-amyloid 1-40 molecule. the lowest detection limit of the assay system for β-amyloid 1-40 was found as 1fg/ml.