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Background and Objectives Inflammatory and obstructive diseases of the salivary glandscan cause recurrent pain, swelling, and dry mouth, significantly affecting the quality of life. Inmost cases, symptoms improve after medical treatment, but if symptoms persist or recur, othertreatment methods should be considered. The purpose of this study was to evaluate the thera-peutic effect of salivary duct steroid irrigation in refractory chronic sialadenitis. Subjects and Method A retrospective study was conducted on 19 patients who underwentStensen’s duct steroid irrigation from January 2016 to December 2021. All patients enrolled instudy had no improvement of symptoms after medical treatment. The clinical characteristicsincluding etiology, location, symptom duration, underlying disease, treatment response andcomplications of the patients were analyzed. Results Stensen’s duct steroid irrigation was effective in 12 of 19 patients (63%), of which 5(26%) showed complete disappearance of symptoms. There was no difference in the treatmenteffect by etiology. The rate of non-response to treatment was high when the symptom durationwas more than one year. Temporary parotid gland swelling occurred in two patients after irri-gation, while other side effects such as bleeding and infection did not occur. Conclusion Salivary duct steroid irrigation is a simple and safe procedure, which may beconsidered as a treatment method for medically refractory chronic sialadenitis.