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Objectives: Portal sites have become places to share queries about performing nursing and obtain expert know-how. Thisstudy aimed to analyze topics of interest in the field of infusion nursing among nurses working in clinical settings. Methods:In total, 169 user query data were collected from October 5, 2018 to December 25, 2021. This exploratory study analyzed thesemantic structure of posts on the nurse question-and-answer board of an infusion nursing-related internet portal by extractingmajor keywords through text data analysis and conducting term frequency (TF) and term frequency-inverse documentfrequency (TF-IDF) analysis, N-gram analysis, and CONvergence of iteration CORrelation (CONCOR) analysis. Word cloudvisualization was conducted utilizing the “wordcloud” package of Python to provide a visually engaging and concise summaryof information about the extracted terms. Results: “Infusion” was the most frequent keyword and the highest-importanceword. “Infusion→line” had the strongest association, followed by “vein→catheter,” “line→change,” and “peripheral→vein.”Three topics were identified: the replacement of catheters, maintenance of the patency of the catheters, and securement of peripheralintravenous catheters, and the subtopics were blood sampling through central venous catheter, peripherally insertedcentral catheter management, evidence-based infusion nursing, and pediatric infusion nursing. Conclusions: These findingsindicate that nurses have various inquiries in infusion nursing. It is necessary to re-establish the duties and roles of infusionnurses, and to develop effective infusion nursing training programs.