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National R&D is being conducted to apply aptamer, which is an eco-friendly bio-material thatcan be combined with specific ionic elements, to the treatment of liquid radioactive waste generated fromdecommissioning of nuclear power plant. In this paper, we evaluated the exposure dose rate of a radiationworker and proposed reduction methods of radiation exposure in post-treatment of aptamer saturatedwith ionic elements after treatment of liquid radioactive waste generated from RVI’s underwatercutting. The evaluation used MCNP code and considered two cases of treating liquid radioactive wasteby embedding all element-specific aptamers developed for a particular element in a single columnand treating liquid radioactive waste by separately embedding the aptamers developed for a particularelement in an element-specific column. It was evaluated that if Co, which accounts for more than 99% of aworker’s exposure, is treated separately from other elements during liquid radioactive waste treatment,it can be advantageous in terms of exposure to a worker by reducing the waste’s volume and treatmenttime and that wearing of lead apron can reduce the dose rate by 12%.