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Polycystic ovarian syndrome (PCOS) is a common endocrine disorder in women of reproductive age and is associated with anincreased risk of obesity, compensatory hyperinsulinemia, dyslipidemia, metabolic syndrome, and endometrial cancer. Thisstudy analyzed 544619 women using the Korean Informative Classification of Disease, version 10, codes E28.0–E28.9 in the popu lation-based National Health Information Databases from 2010 to 2019. The age-adjusted incidence and prevalence rates of PCOSover 10 years among Korean women were 2.8% and 4.3%, respectively; and they increased in the late teens, peaked in the 20s, andbegan to decrease at the age of 30. We also found that the body mass index, levels of fasting blood glucose, and high-density lipo protein values in the recent two years (2018–2019) were higher in women with PCOS compared to the general population. This is thefirst study to investigate the prevalence of PCOS in a nationwide population of reproductive-aged Korean women. Further researchis needed to examine the short- and long-term health risks and psychological problems associated with PCOS.