@article{ART002857368,
author={Kim Jieun and Kim Jinyeong and Kim Bongyoung and Pai Hyunjoo},
title={Which is the Preferred Regimen for Non-Severe Clostridioides difficile Infection in Korea, Vancomycin or Metronidazole?},
journal={Infection and Chemotherapy},
issn={2093-2340},
year={2022},
volume={54},
number={2},
pages={213-219},
doi={10.3947/ic.2022.0027},
url={https://icjournal.org/DOIx.php?id=10.3947/ic.2022.0027}
}

TY - JOUR
AU - Kim Jieun
AU - Kim Jinyeong
AU - Kim Bongyoung
AU - Pai Hyunjoo
TI - Which is the Preferred Regimen for Non-Severe Clostridioides difficile Infection in Korea, Vancomycin or Metronidazole?
T2 - Infection and Chemotherapy
JO - Infection and Chemotherapy
PY - 2022
VL - 54
IS - 2
PB - 대한감염학회
SP - 213
EP - 219
SN - 2093-2340
AB - The emergence of hypervirulent Clostridioides difficile strains has decreased the efficacy of metronidazole in the treatment of C. difficile infection (CDI). Therefore, revised guidelines no longer recommend the use of metronidazole as a first-line regimen for CDI and restrict its use for non-severe CDI, only when vancomycin and fidaxomicin are unavailable. In Korea, an epidemic caused by a hypervirulent C. difficile strain or the emergence of metronidazole resistant C. difficile strains have not been reported. This review article aims to compare the treatment outcomes and adverse effects of vancomycin and metronidazole and discuss the validity of the guidelines of various agencies, which restrict the use of metronidazole, for Korean patients. There are no substantial adverse effects of metronidazole, and its clinical outcomes against non-severe CDI are similar to those of vancomycin. Based on these findings, we recommend that the use of metronidazole for the treatment of non-severe CDI is still an appropriate option in Korea.
KW - Clostridioides difficile infection, Treatment, Metronidazole, Vancomycin
DO - 10.3947/ic.2022.0027
UR - https://icjournal.org/DOIx.php?id=10.3947/ic.2022.0027
ER -

Kim Jieun, Kim Jinyeong, Kim Bongyoung and Pai Hyunjoo. 2022, "Which is the Preferred Regimen for Non-Severe Clostridioides difficile Infection in Korea, Vancomycin or Metronidazole?", Infection and Chemotherapy, vol.54, no.2 pp.213-219. Available from: doi:10.3947/ic.2022.0027

Kim Jieun, Kim Jinyeong, Kim Bongyoung, Pai Hyunjoo "Which is the Preferred Regimen for Non-Severe Clostridioides difficile Infection in Korea, Vancomycin or Metronidazole?" Infection and Chemotherapy 54.2 pp.213-219 (2022) : 213.

Kim Jieun, Kim Jinyeong, Kim Bongyoung, Pai Hyunjoo. Which is the Preferred Regimen for Non-Severe Clostridioides difficile Infection in Korea, Vancomycin or Metronidazole?. 2022; 54(2), 213-219. Available from: doi:10.3947/ic.2022.0027

Kim Jieun, Kim Jinyeong, Kim Bongyoung and Pai Hyunjoo. "Which is the Preferred Regimen for Non-Severe Clostridioides difficile Infection in Korea, Vancomycin or Metronidazole?" Infection and Chemotherapy 54, no.2 (2022) : 213-219.doi: 10.3947/ic.2022.0027

Kim Jieun; Kim Jinyeong; Kim Bongyoung; Pai Hyunjoo. Which is the Preferred Regimen for Non-Severe Clostridioides difficile Infection in Korea, Vancomycin or Metronidazole?. Infection and Chemotherapy, 54(2), 213-219. doi: 10.3947/ic.2022.0027

Kim Jieun; Kim Jinyeong; Kim Bongyoung; Pai Hyunjoo. Which is the Preferred Regimen for Non-Severe Clostridioides difficile Infection in Korea, Vancomycin or Metronidazole?. Infection and Chemotherapy. 2022; 54(2) 213-219. doi: 10.3947/ic.2022.0027

Kim Jieun, Kim Jinyeong, Kim Bongyoung, Pai Hyunjoo. Which is the Preferred Regimen for Non-Severe Clostridioides difficile Infection in Korea, Vancomycin or Metronidazole?. 2022; 54(2), 213-219. Available from: doi:10.3947/ic.2022.0027

Kim Jieun, Kim Jinyeong, Kim Bongyoung and Pai Hyunjoo. "Which is the Preferred Regimen for Non-Severe Clostridioides difficile Infection in Korea, Vancomycin or Metronidazole?" Infection and Chemotherapy 54, no.2 (2022) : 213-219.doi: 10.3947/ic.2022.0027