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This paper presents a digitally interfaced a 128-channel recording, 32-channel stimulation optogenetic neuromodulation system on chip (SoC) that has been developed for long-term optogenetics neuroscience research. The low-power 128-channel neural recording frontend offers low-noise multichannel recording, on-chip 16-bit data digitization, and electrode impedance measurement. The 32-channel optogenetic stimulator provides high-resolution, accurate optical stimulation. The chip communicates through two control signal shared SPI interfaces for simultaneous recording and stimulation with independent on-the-fly control command and data transfer, resulting in only 6 external wires. The developed system constitutes a fully digital, bidirectional 128/32-channel SoC suitable for in-vivo neuromodulation.
