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Relapsing polychondritis is a rare multisystemic disease which affects cartilaginous tissues of auricles, nose, larynx, trachea and joints as well as proteoglycan-rich structures. The disease is characterized by repetitive inflammatory and destructive episodes. Chondritis most frequently involves external ear, but the spectrum of clinical presentations may vary from intermittent episodes of painful chondritis and ocular inflammation, to organ or even life-threatening manifestations like cardiovascular complications and airway collapse. Its pathogenesis in not determined completely. In the treatment, main medication is a corticosteroid and immunosuppressive drugs represent a second-choice treatment. Authors have recently experienced a case of relapsing polychondritis in a 42 year old man who had ear fullness as an initial manifestation. We report this case with a review of the literature.
