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ObjectiveTo evaluate the effects of maternal body mass index (BMI) and plurality on maternal and umbilical cord serummagnesium levels after antenatal magnesium sulfate treatment. MethodsThis was a retrospective cohort analysis of 135 women treated with antenatal magnesium sulfate at less than32 weeks of gestation between January 2012 and June 2018. Subjects were stratified into groups according tomaternal BMI (group I [18.5–22.9 kg/m²], group II [23.0–24.9 kg/m²], and group III [≥25.0 kg/m²]) and plurality (singletonand twin). Univariable and multivariable analyses were performed to compare the umbilical cord serum magnesiumlevels between the groups. ResultsMaternal serum magnesium levels were not significantly different between the maternal BMI groups and singletonand twin pregnancies. Umbilical cord serum magnesium levels were significantly different among the maternal BMIgroups (3.3±1.2 mg/dL in group I, 3.3±1.2 mg/dL in group II, and 4.0±1.4 mg/dL in group III, P=0.003). The trend ofincrease in magnesium levels was statistically significant (P=0.001, Jonckheere-Terpstra test). Umbilical cord serummagnesium levels were not significantly different according to plurality. However, in the multivariable analysis,maternal BMI and plurality were not significantly associated with umbilical cord serum magnesium levels afteradjusting for indication and total dose of magnesium sulfate treatment, gestational age at delivery, mode of delivery,neonatal sex, and birth weight. ConclusionMaternal BMI and plurality were not significantlyassociated with maternal or umbilical cord serummagnesium levels after exposure to antenatalmagnesium sulfate treatment.
