초록 열기/닫기 버튼
Neuronal loss and axonal degeneration after spinal cord injury or peripheral injury result in the loss of sensory and motor functions. Nerve regeneration is a complicated and medical challenge that requires suitable guides to bridge nerve injury gaps and restorenerve function. Due to the hostility of the microenvironment in the lesion, multiple conditions should be fulfilled to achieveimproved functional recovery. Many nerve conduits have been fabricated using various natural and synthetic polymers. The designand material of the nerve guide conduits were carefully reviewed. A detailed review was conducted on the fabrication methodof the nerve guide conduit for nerve regeneration. The typical fabrication methods used to fabricate nerve conduits are dipcoating, solvent casting, micropatterning, electrospinning, and additive manufacturing. The advantages and disadvantages of thefabrication methods were reported, and research to overcome these limitations was reviewed. Extensive reviews have focused onthe biological functions and in vivo performance of polymeric nerve conduits. In this paper, we emphasize the fabrication methodof nerve conduits by polymers and their properties. By learning from the existing candidates, we can advance the strategies fordesigning novel polymeric systems with better properties for nerve regeneration.
