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Bilateral sudden sensorineural hearing loss (SSNHL) is rare and usually indicates a serioussystemic pathology. We describe an unusual case of bilateral SSNHL caused by sepsis. A28-year-old female complained of acute-onset bilateral hearing impairment; in addition tootological symptoms, she had a systemic condition that met the criteria for sepsis. We performeda physical examination and laboratory tests to diagnose sepsis. Pure tone audiogramand videonystagmography were performed to evaluate the otological symptoms. Intravenousantibiotics and high-dose methylprednisolone were prescribed for treatment, and audiogramwas repeated during that period. The fever subsided and the vital signs were stabilized. Theelectrolyte imbalance and abnormal urine parameters became normal. Hearing gradually recoveredto a normal level on day 7 of hospitalization. In conclusion, sepsis should be consideredas a cause of SSNHL. When conducting a detailed examination of patients with bilateralSSNHL, the clinician should consider systemic disease.