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Objectives: The purpose of this study was to examine the mediating effects of economic distress and social capital on the relationship between burnout and happiness of nursing students. Methods: This study used Maslach Burnout Inventory-Student Survey, The Oxford Happiness Questionnaire, Incharge Financial Distress/Financial Well-Being Scale, and Internet Social Capital Scales. The data was analyzed by using frequency, percentage, mean, standard deviation, t-test, one-way ANOVA, and Person’s correlation coefficient. Baron and Kenny’s method was used to analyze mediating effect between burnout and happiness. Results: Burnout, happiness, social capital, and economic distress had correlation with each other. There were the mediating effects of economic distress and social capital on the relationship between burnout and happiness of respondents. Conclusions: The result showed the mediating effects of economic distress and social capital on the relationship between burnout and happiness of nursing students. To increase happiness, it is necessary to apply a curriculum to strengthen the ability of nursing students.