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The medical education in Korea began in 1885 at the Che Jung Won Medical School, which was succeeded by the present-day Yonsei University College of Medicine. This article is aimed at summarizing the trend of medical education in Korea for the past 20 years and elucidating the role of Yonsei University College of Medicine in three aspects. The first is the specialization in medical education. In the past, the traditional apprenticeship training program had been conducted in medical colleges, which was apart from the specialization. However, along with the Korean Society of Medical Education and the Korean Association of Medical School Deans founded in 1983 and 1984, respectively, the Department of Medical Education in Yonsei University established in 1994 has enabled the immediate specialization in medical education. The second is the innovation of the curriculum. In particular, Yonsei University has made a big change by reducing the lecture time to 60%, opening elective courses, and implementing systematic education of humanities and social medicine since 2004 through the Curriculum Development Project. Subsequently, major changes were made in the new curriculum introduced in 2013, which adopted an absolute evaluation system, encouraged students' research and social activities, and created learning communities. The third is student development with a holistic approach. Medical education not only involves imparting medical knowledge, but also entails teaching professionalism and responsibilities to society, enhancing students’ ability to work as a team, and career guidance as well. In this context, Yonsei University has introduced a learning community since 2014, showing a specific model of abovementioned properties. The task of future medical education is to innovate learning methods, to adapt to the advent of the era of artificial intelligence, and to develop people with genuine curiosity, enthusiasm, and responsibility.