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This study is to determine the radioprotective effects of Squalene (SQ) extracted fromnatural products, a large amount of which is contained in the liver of centrophorusatromarginatus. For this purpose, SQ was administered to mice exposed to a session of 3 Gy whole-body irradiation;then, first, Caspase-3 and Caspase-9 in the cell signaling pathways, which led to apoptosis, weremeasured to examine cell activity; second, nitric oxide (NO) was measured to observe inflammatoryresponses in cells. There were a total of seven experimental groups; considering the fact that it mighttake the specimens long to be absorbed into living tissues, seven- and three-day factors were appliedto the pretreatment groups and three- and seven-day factors. To determine the radioprotectiveeffects of SQ, a 10 MeV LINAC radiation therapy system was used to expose mice to a session ofwhole-body irradiation in a dose of 3 Gy, which induces the greatest biochemical changes in livingtissues, at the dose rate of 300 cGy·min-1. It has been confirmed that squalene with good antioxidanteffects gives radioprotection by promoting NO generation and by inhibiting Caspase that a naturalproduct with a lower level of chemical toxicity can be used as a radioprotector.
