초록 열기/닫기 버튼
Stereotactic body radiation therapy (SBRT) is an important treatment option for pancreatic cancer, which is known to be one of themalignancies with the worst prognosis. However, the high radiation doses delivered during SBRT may cause damage to adjacentradiosensitive organs. To minimize such damage, fiducial markers are used for localization during SBRT for pancreatic cancer. Thedevelopment of endoscopic ultrasound (EUS) has enabled fiducial markers to be inserted into the pancreas using an EUS fine-needleaspiration (FNA) needle, unlike in the past when percutaneous placement was generally performed. For successful EUS-guidedfiducial marker placement, it is necessary for the fiducial markers to be loaded within the EUS-FNA needles to have a low probabilityof complications and a low migration risk, and to be stably observed in SBRT imaging. A systematic review has shown that thetechnical success rate of EUS-guided fiducial marker placement is 96.27%, whereas the fiducial marker migration and adverse eventrates are 4.33% and 4.85%, respectively. Nonetheless, standardized techniques for fiducial marker placement and the characteristicsof optimal fiducial markers have not yet been established. This review will introduce the characteristics (e.g., materials and shapes) offiducial markers used in fiducial marker placement for pancreatic cancer and will discuss conventional techniques along with theirsuccess rates, difficulties, and adverse events.
