@article{ART002674613,
author={Pan Yibin and Yan Lili and Chen Qiaoqiao and Wei Cheng and Dai Yongdong and Tong Xiaomei and Zhu Haiyan and Lu Meifei and Zhang Yanling and Jin Xiaoying and Zhang Tai and Lin Xiaona and Zhou Feng and Zhang Songying},
title={Dysfunction of Shh signaling activates autophagy to inhibit trophoblast motility in recurrent miscarriage},
journal={Experimental and Molecular Medicine},
issn={1226-3613},
year={2021},
volume={53},
pages={1-15},
doi={10.1038/s12276-020-00530-6}
}

TY - JOUR
AU - Pan Yibin
AU - Yan Lili
AU - Chen Qiaoqiao
AU - Wei Cheng
AU - Dai Yongdong
AU - Tong Xiaomei
AU - Zhu Haiyan
AU - Lu Meifei
AU - Zhang Yanling
AU - Jin Xiaoying
AU - Zhang Tai
AU - Lin Xiaona
AU - Zhou Feng
AU - Zhang Songying
TI - Dysfunction of Shh signaling activates autophagy to inhibit trophoblast motility in recurrent miscarriage
T2 - Experimental and Molecular Medicine
JO - Experimental and Molecular Medicine
PY - 2021
VL - 53
IS - null
PB - 생화학분자생물학회
SP - 1
EP - 15
SN - 1226-3613
AB - In early pregnancy, the placenta anchors the conceptus and supports embryonic development and survival. This study aimed to investigate the underlying functions of Shh signaling in recurrent miscarriage (RM), a serious disorder of pregnancy. In the present study, Shh and Gli2 were mainly observed in cytotrophoblasts (CTBs), Ptch was mainly observed in syncytiotrophoblasts (STBs), and Smo and Gli3 were expressed in both CTBs and STBs. Shh signaling was significantly impaired in human placenta tissue from recurrent miscarriage patients compared to that of gestational age-matched normal controls. VEGF-A and CD31 protein levels were also significantly decreased in recurrent miscarriage patients. Furthermore, inhibition of Shh signaling impaired the motility of JAR cells by regulating the expression of Gli2 and Gli3. Intriguingly, inhibition of Shh signaling also triggered autophagy and autolysosome accumulation. Additionally, knockdown of BECN1 reversed Gant61-induced motility inhibition. In conclusion, our results showed that dysfunction of Shh signaling activated autophagy to inhibit trophoblast motility, which suggests the Shh pathway and autophagy as potential targets for RM therapy.
KW -
DO - 10.1038/s12276-020-00530-6
ER -

Pan Yibin, Yan Lili, Chen Qiaoqiao, Wei Cheng, Dai Yongdong, Tong Xiaomei, Zhu Haiyan, Lu Meifei, Zhang Yanling, Jin Xiaoying, Zhang Tai, Lin Xiaona, Zhou Feng and Zhang Songying. 2021, "Dysfunction of Shh signaling activates autophagy to inhibit trophoblast motility in recurrent miscarriage", Experimental and Molecular Medicine, vol.53, pp.1-15. Available from: doi:10.1038/s12276-020-00530-6

Pan Yibin, Yan Lili, Chen Qiaoqiao, Wei Cheng, Dai Yongdong, Tong Xiaomei, Zhu Haiyan, Lu Meifei, Zhang Yanling, Jin Xiaoying, Zhang Tai, Lin Xiaona, Zhou Feng, Zhang Songying "Dysfunction of Shh signaling activates autophagy to inhibit trophoblast motility in recurrent miscarriage" Experimental and Molecular Medicine 53 pp.1-15 (2021) : 1.

Pan Yibin, Yan Lili, Chen Qiaoqiao, Wei Cheng, Dai Yongdong, Tong Xiaomei, Zhu Haiyan, Lu Meifei, Zhang Yanling, Jin Xiaoying, Zhang Tai, Lin Xiaona, Zhou Feng, Zhang Songying. Dysfunction of Shh signaling activates autophagy to inhibit trophoblast motility in recurrent miscarriage. 2021; 53 1-15. Available from: doi:10.1038/s12276-020-00530-6

Pan Yibin, Yan Lili, Chen Qiaoqiao, Wei Cheng, Dai Yongdong, Tong Xiaomei, Zhu Haiyan, Lu Meifei, Zhang Yanling, Jin Xiaoying, Zhang Tai, Lin Xiaona, Zhou Feng and Zhang Songying. "Dysfunction of Shh signaling activates autophagy to inhibit trophoblast motility in recurrent miscarriage" Experimental and Molecular Medicine 53(2021) : 1-15.doi: 10.1038/s12276-020-00530-6

Pan Yibin; Yan Lili; Chen Qiaoqiao; Wei Cheng; Dai Yongdong; Tong Xiaomei; Zhu Haiyan; Lu Meifei; Zhang Yanling; Jin Xiaoying; Zhang Tai; Lin Xiaona; Zhou Feng; Zhang Songying. Dysfunction of Shh signaling activates autophagy to inhibit trophoblast motility in recurrent miscarriage. Experimental and Molecular Medicine, 53, 1-15. doi: 10.1038/s12276-020-00530-6

Pan Yibin; Yan Lili; Chen Qiaoqiao; Wei Cheng; Dai Yongdong; Tong Xiaomei; Zhu Haiyan; Lu Meifei; Zhang Yanling; Jin Xiaoying; Zhang Tai; Lin Xiaona; Zhou Feng; Zhang Songying. Dysfunction of Shh signaling activates autophagy to inhibit trophoblast motility in recurrent miscarriage. Experimental and Molecular Medicine. 2021; 53 1-15. doi: 10.1038/s12276-020-00530-6

Pan Yibin, Yan Lili, Chen Qiaoqiao, Wei Cheng, Dai Yongdong, Tong Xiaomei, Zhu Haiyan, Lu Meifei, Zhang Yanling, Jin Xiaoying, Zhang Tai, Lin Xiaona, Zhou Feng, Zhang Songying. Dysfunction of Shh signaling activates autophagy to inhibit trophoblast motility in recurrent miscarriage. 2021; 53 1-15. Available from: doi:10.1038/s12276-020-00530-6

Pan Yibin, Yan Lili, Chen Qiaoqiao, Wei Cheng, Dai Yongdong, Tong Xiaomei, Zhu Haiyan, Lu Meifei, Zhang Yanling, Jin Xiaoying, Zhang Tai, Lin Xiaona, Zhou Feng and Zhang Songying. "Dysfunction of Shh signaling activates autophagy to inhibit trophoblast motility in recurrent miscarriage" Experimental and Molecular Medicine 53(2021) : 1-15.doi: 10.1038/s12276-020-00530-6